Coronavirus Antibody Test Cross Reactivity

SARS-CoV is genetically related to SARS-CoV-2 sharing approximately 80 sequence identity and both belong to the species SARS related coronavirus in the genus Betacoronavirus of family Coronaviridae. A preliminary study of human sera collected prior to the SARS-CoV-2 pandemic demonstrates overall high IgG reactivity to common human coronaviruses and low IgG reactivity to epidemic coronaviruses including SARS-CoV-2 with some cross-reactivity of conserved antigenic domains including S2 domain of spike protein and nucleocapsid protein.

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3 As immunodeficiency can lead to false-negative serology results the measurements of total IgG and total IgM should be considered along with any history of immunodeficiency.

Coronavirus antibody test cross reactivity. Heres the tricky part. Unlike PCR tests which are highly specific cross-reactivity is a major challenge for COVID-19 antibody tests considering there are six other coronaviruses known to infect humans. Diana Yu Thurston Countys Acting Health officer said in an email that antibody.

CDCs serologic test has a specificity of greater than 99 and a sensitivity of 96 based on performance evaluations. The potential role of low-pathogenic human coronaviruses The human body is capable of producing antibodies in response to severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection the causative agent of COVID-19. Lastly there has been discussion about whether RDTs detecting antibodies could predict whether an individual was immune to reinfection with the COVID-19 virus.

Antibody detection tests targeting COVID-19 may also cross-react with other pathogens including other human coronaviruses. This is because theres a lower chance that youve been exposed to the virus so theres a higher chance a positive result is due to cross reactivity in the test. However potential cross-reactivity cannot be completely ruled out.

The lower the prevalence of COVID-19 in your community the higher the chance for error in the antibody test. The severe acute respiratory syndrome coronavirus SARS-CoV caused a worldwide epidemic in late 2002early 2003 and a second outbreak in the winter of 20032004 by an independent animal-to-human transmission. COVID-19 patient sera also exhibited a significantly higher level of reactivity to seasonal HCoV peptides than did sera from preCOVID-19 era controls Fig.

The GD03 strain which was isolated from an index patient of the second outbreak was reported to resist neutralization by the human monoclonal antibodies hmAbs 80R. Cross-reactivity refers to the antibody test not distinguishing between the different strains of coronavirus. This test is designed to minimize cross-reactivity to antibodies generated to other common coronaviruses that cause less severe illnesses such as colds.

71516 and give false-positive results. Cross-reaction of severe acute respiratory syndrome coronavirus antigen with autoantibodies in autoimmune diseases was previously reported.

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